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Karyotyping May Be Warranted for isolated Talipes.
ST. JOHN'S, NFLD, -- Fetal karyotyping may still be warranted when isolated talipes is found on ultrasound, Dr. Tina Delaney said at the annual meeting of the Society of Obstetricians and Gynaecologists of Canada.
Historically, the literature on the incidence of chromosomal abnormalities with prenatally diagnosed talipes has been limited and conflicting. And recently the tide seems to be turning against the need for karyotyping in cases of isolated talipes, explained Dr. Delaney of the department
Of obstetrics and gynecology at Dalhousie University, Halifax, N.S.
In a study of 51 fetuses diagnosed with isolated talipes on ultrasound, no cases of aneuploidy were found by fetal karyotype evaluation or by newborn physical examination. This finding prompted researchers to conclude that karyotyping is unnecessary provided that a detailed sonographic anatomy survey is normal (Obstet. Gynecol. 95[3]:437-40, 2000).
In a study aimed at determining the rate of chromosomal abnormalities in neonates born with talipes, Dr. Delaney and associates examined the medical charts of 285 fetuses or neonates with bilateral or unilateral talipes.
All data were culled from the Nova Scotia Atlee Perinatal Database, 1992-2000.
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