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Estrogen therapy in postmenopausal, hypothyroid women elicits a clinically significant decrease in serum free thyroxine, results of a small study suggest.
These findings suggest that doctors who prescribe estrogen for postmenopausal, hypothyroid: women on thyroxine should measure their patients' serum thyrotropin levels approximately 12 weeks after starting estrogen therapy, said Dr. Baha M. Arafah of Case Western Reserve University, Cleveland (N. Engl. J. Med. 344[23]:1743-49, 2001).
"Women who are taking thyroxine may need more thyroxine when they are treated-with estrogen and may need less-thyroxine after estrogen is discontinued," said Dr. Robert D. Utiger in an accompanying editorial (N. Engl.J. Med. 344 [23]1784-85, 2001).
The study compared 11 euthyroid women and 25 women with -primary hypothyroidism who were ...