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Is the diet drug sibutramine (Meridia) too dangerous to stay on the market? The Health Research Group at Public Citizen, a Washington-based consumer-advocacy organization, says it is, citing adverse events reported to the Food and Drug Administration.
From the drug's introduction in February 1998 through March of this year, the FDA received reports of 49 deaths from cardiac arrest, heart attack, and heart arrhythmia in people who were taking sibutramine. Another 124 people developed cardiovascular conditions severe enough to require hospitalization. The manufacturer, Abbott Laboratories, declined to tell us how many people are taking the drug.
"We would like nothing better than to see an effective weight-loss drug, but Meridia is not it," says Larry D. Sasich, Pharm.D., M.P.H., a researcher at Public Citizen. Obese people already are at risk for high blood pressure and heart problems. "So, the very people who would benefit most from weight loss face substantial risk from this drug," says Sasich.
Sibutramine encourages weight loss in part by stimulating the sympathetic nervous system, which boosts heart rate and blood pressure. The mechanism is similar to that of amphetamines, as well as nutritional supplements containing ephedra, which have also been linked to ...