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Finasteride, taken at a higher dosage than is approved for male androge-netic alopecia, improved female pattern hair loss in 23 of 37 premenopausal women who used it for 1 year, reported Dr. Matilde Iorizzo and her associates at the University of Bologna, Italy.
It appears that the approved dosage of 1 mg/day may be inadequate for treating female pattern hair loss. In this study, 2.5 mg/day was well tolerated, and none of the study subjects reported adverse events, the researchers noted.
Finasteride is teratogenic and contraindicated in women of child-bearing potential; its use in these premenopausal women required concomitant treatment with an oral contraceptive. Ethinyl estradiol-drospirenone was selected because it was theorized that drospirenone's antian-drogenic activity might have an adjuvant effect on female pattern hair loss, Dr. Iorizzo and her associates said (Arch. ...