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Female pattern hair loss may need more finasteride.(Clinical Rounds)

OB GYN News

| May 01, 2006 | Moon, Mary Ann | COPYRIGHT 2006 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

Finasteride, taken at a higher dosage than is approved for male androge-netic alopecia, improved female pattern hair loss in 23 of 37 premenopausal women who used it for 1 year, reported Dr. Matilde Iorizzo and her associates at the University of Bologna, Italy.

It appears that the approved dosage of 1 mg/day may be inadequate for treating female pattern hair loss. In this study, 2.5 mg/day was well tolerated, and none of the study subjects reported adverse events, the researchers noted.

Finasteride is teratogenic and contraindicated in women of child-bearing potential; its use in these premenopausal women required concomitant treatment with an oral contraceptive. Ethinyl estradiol-drospirenone was selected because it was theorized that drospirenone's antian-drogenic activity might have an adjuvant effect on female pattern hair loss, Dr. Iorizzo and her associates said (Arch. ...

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