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Nifedipine faster, safer than magnesium sulfate.(Obstetrics)
MIAMI BEACH -- Oral nifedipine is a faster acting and safer tocolytic than magnesium sulfate is, findings of a recent randomized study suggest.
A total of 192 women who presented between 24 and 34 weeks' gestation with contractions and cervical change or ruptured membranes were enrolled in the study. Of those randomized to receive nifedipine, significantly fewer achieved uterine quiescence (12 hours of six or fewer contractions per hour and no further cervical change within 48 hours), compared with the magnesium sulfate group (72% vs. 87%), Dr. Deirdre J. Lyell reported at the annual meeting of the Society for Maternal-Fetal Medicine.
However, in those who achieved quiescence, nifedipine acted within 6 hours vs. 8 hours for magnesium sulfate, and 34% of patients in the nifedipine group experienced side effects, compared with 65% in the magnesium sulfate group, said Dr. Lyell of Stanford (Calif.) University.
No side effects were significantly increased with nifedipine, compared with magnesium sulfate, although there was a trend toward greater risk for headache with nifedipine. Serious side effects such as shortness of breath were significantly more common with magnesium sulfate, and the ...
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