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Thrombophilia not at fault in fetal losses.(Obstetrics)
TORONTO -- Recurrent pregnancy loss was not associated with inherited maternal thrombophilias in a prospective study, adding weight to the evidence against screening for such disorders in patients presenting with a history of first-trimester miscarriage.
"It's probably more important to rule out other possible etiological factors," said lead investigator Dr. Sony Sierra in an interview.
The study, which she presented at the annual meeting of the Society for Gynecologic Investigation, genotyped 915 Hutterite women for inherited thrombophilia polymorphisms including Factor V Leiden (FVL) Arg506Gln, the MTHFR Ala222Val, and the prothrombin G20210A variants. A total of 141 women were identified with inherited thrombophilias and were prospectively followed through 342 pregnancies.
The rate of fetal loss, defined as loss at or before 20 weeks of gestation, was 16% in the cohort, which is comparable to the rate found in the general population, reported Dr. Sierra, of the department of obstetrics and gynecology at the University of British Columbia in Vancouver.
"We also found that the majority of ...
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