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"When sensitivities to light, noises, or smells go straight to your head, don't hide in the dark--reach for the herbal support of feverfew." So reads the claim on www.swansonvitamins.com, one of the many Web sites marketing the herb feverfew as a migraine preventive. By law, supplement manufacturers can't claim medical benefits. But benefits are implied by product names such as "MygrAid" (Nature's Way) or "Migr-Ease" (Crystal Star Herbal Nutrition). And ads typically note the product's concentration of the compound parthenolide, said to ward off headaches by helping to "maintain normal blood vessel tone" or "reducing serotonin release from platelets."
But experts say feverfew's effectiveness has not been proven. Some early laboratory evidence suggested that parthenolide from fresh feverfew leaves helped keep blood constricting and normalize levels of the brain chemical serotonin; in theory, those actions could help fend off migraines. But newer evidence suggests these pharmacological effects may not derive from the parthenolide in feverfew, throwing doubt on product claims based on ...