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Anogenital IN found to require lengthy surveillance term.(Gynecology)(intraepithelial neoplasia)(Brief article)
ATLANTA -- High-grade anogenital intraepithelial neoplasia has remarkably high recurrence and malignancy potential despite repeated treatments; thus long-term surveillance is mandatory, according to Dr. Mathias K. Fehr of University Hospital, Zurich, Switzerland.
A retrospective study of 442 patients with biopsy-proven grade 2-3 intraepithelial neoplasia of the vulva (VIN), vagina (VAIN), or perianal skin (PAIN) showed that progression to invasive disease occurred in 4% of the 433 treated patients within a mean of 8 years, Dr. Fehr reported in a poster at the annual meeting of the American Society of Clinical Oncology.
Recurrent disease, defined as VIN, VAIN, or PAIN diagnosed at least 1 year after the initial diagnosis, occurred in 32% of the treated patients, and among treated patients with a follow-up of longer than 5 ...
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