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Anogenital findings raise concerns about phthalates.(anogenital diseases of male infants)
SAN DIEGO -- Pregnant women exposed to relatively high levels of a common household chemical compound gave birth to male infants with significant reductions in anogenital distance and smaller-than-average penile volume, scrotal development, and testicular descent.
Anogenital distance, while rarely studied in humans, is believed to be a marker of antiandrogenic action, with possible implications for fertility later in life.
Preliminary results from a multicenter study found a 10-fold difference in the anogenital measurement in boys born to women exposed to high levels versus low levels of a certain phthalate, a compound used in making plastics and other products in everyday use.
The power of the association between phthalate exposure and anogenital findings in male babies was strong, and merits considerably more study, said Shanna H. Swan, Ph.D., professor of obstetrics and gynecology, environmental medicine, and community and preventive health at the University of Rochester (N.Y.).
She presented preliminary findings of the ongoing study at the Forum on Endocrine Disrupting Chemicals, held in conjunction with the annual meeting of the Endocrine Society.
"The exposure levels were not all that high," Dr. Swan said.
Phthalates are virtually ubiquitous in society, found in paint, plastics, perfumes, cosmetics, nail polish, deodorant, cleaners, carpet backing, dust, and pesticides.
- Anogenital findings raise phthalate concerns.(News)
- Magazine article from: Family Practice News Bates, Betsy July 15, 2005 700+ words
...phthalate exposure and anogenital findings in male babies was strong...by weight to obtain an anogenital index for each child. Four phthalate...shorter-than-predicted anogenital index than were sons of women...infants to have a short anogenital index. The ...
- Phthalate exposure during pregnancy and lower anogenital index in boys: wider...
- Magazine article from: Environmental Health Perspectives Sharpe, Richard M. August 1, 2005 700+ words
...and masculinization in rats. Swan et al. (2005) challenge this view by showing a negative relationship between the anogenital index (AGI) in boys 2-30 months of age and the level of phthalate metabolites in maternal urine during the index pregnancy...
- Phthalate exposure in pregnancy may affect male offspring.(News)
- Magazine article from: Internal Medicine News Bates, Betsy August 1, 2005 700+ words
...phthalate exposure and anogenital findings in male babies was strong...by weight to obtain an anogenital index for each child. Four phthalate...shorter-than-predicted anogenital index than were sons of women...infants to have a short anogenital index. The ...
- Estimated daily phthalate exposures in a population of mothers of male infants...
- Magazine article from: Environmental Health Perspectives Marsee, Kevin Woodruff, Tracey J. Axelrad, Daniel A. Calafat, Antonia M. Swan, Shanna H. June 1, 2006 700+ words
...monoisobutyl phthalate [MiBP; a metabolite of diisobutyl phthalate (DiBP)] were significantly associated with reduced AGD and anogenital index (AGI = AGD/body weight) in male infants. Although none of the 134 boys examined showed frank malformations or disease...
- Phthalates and male babies.
- News wire article from: Asia Africa Intelligence Wire June 6, 2005 700+ words
...with the highest exposure to phthalates in the womb had the shortest anogenital distance when adjusted for weight - the anogenital index (AGI). Their penises were also smaller and there were more cases of testes that had not descended. "In rodents, the...
- Decrease in anogenital distance among male infants with prenatal phthalate...
- Magazine article from: Environmental Health Perspectives Swan, Shanna H. Main, Katharina M. Liu, Fan Stewart, Sara L. Kruse, Robin L. Calafat, Antonia M. Mao, Catherine S. Redmon, J. Bruce Ternand, Christine L. Sullivan, Shannon Teague, J. Lynn August 1, 2005 700+ words
...0.001) and the proportion of boys with incomplete testicular descent (R = 0.20, p = 0.02). We defined the anogenital index (AGI) as AGD divided by weight at examination [AGI = AGD/weight (mm/kg)] and calculated the age-adjusted AGI...
- Study: phthalates affect sexual development.
- News wire article from: Asia Africa Intelligence Wire June 3, 2005 700+ words
...is not clear what the changes mean, and said that the authors of the study admit that one of their key measurements - anogenital index - may not be clinically relevant. The phthalates panel said the connection between phthalate exposure and a small anatomical...
- TOXIC EXPOSURE.
- Newspaper article from: Sarasota Herald Tribune January 20, 2009 700+ words
...during pregnancy and how baby boys' genitals develop. Experts noted that boys with greater phthalate exposure had a small anogenital index (AGI), which coincides with small penis volumes and incomplete testicular development. How to protect yourself: When...
- Prenatal phthalate exposure and anogenital distance in male...
- Magazine article from: Environmental Health Perspectives Swan, Shanna H. February 1, 2006 700+ words
...concentration of phthalate metabolites in maternal prenatal urine and the AGD, or the more appropriate derived measure anogenital index (AGI = AGD/weight), in human male offspring. We designed our study to focus on this specific measurement because...
- Validity of anogenital distance as a marker of in utero phthalate...
- Magazine article from: Environmental Health Perspectives McEwen, Gerald N., Jr. Renner, Gerald January 1, 2006 700+ words
...and weight. To compensate for this variability, Swan et al. (2005) defined a new parameter, which they termed the "anogenital index" (AGI), by dividing AGD by body weight. In the absence of validation, the significance of the AGI is not known...
Source: HighBeam Research, Anogenital findings raise concerns about phthalates.(anogenital...