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Adding ultrasound ups sensitivity of AFP screen to 98%: study.(alpha fetoprotein )
ORLANDO -- Adding ultrasound to maternal serum AFP screening may help clinicians identify fetal neural tube defects, according to research that was presented during the annual meeting of the American Institute of Ultrasound in Medicine.
"From the standpoint of neural tube defect detection, the maternal serum AFP screening test remains a good test--in our series, more neural tube defects were detected if the test was used than if it was not used--but the sensitivity of the test is significantly better if gestational age is confirmed with ultrasound," explained Jodi S. Dashe, M.D., of the University of Texas Southwestern Medical Center, Dallas.
"We were also pleased to find that in this series, the detection of neural tube defects with standard ultrasound was excellent," Dr. Dashe added during the meeting.
Dr. Dashe and her associates conducted a retrospective study at their center to examine the role of ultrasound along with AFP screening for neural tube defects. For this investigation, they reviewed prenatal and neonatal datasets to find pregnancies that were complicated by neural tube defects.
Following their standard protocol, Dr. Dashe's team offered AFP screening between 15 and 21 weeks of gestation and performed specialized ultrasound for patients with an AFP of at least 2.50 multiples of the median (MOM).
For patients with an AFP of 2.00-2.49 MOM, standard ultrasound was performed.
Investigators identified 68 singletons with neural tube defects, 60 of which were identified prenatally.
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Source: HighBeam Research, Adding ultrasound ups sensitivity of AFP screen to 98%: study.(alpha...