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Imaging data from phase III study support parathyroid as bone builder.(Clinical report)
WASHINGTON -- Imaging data from a phase III study confirm that treatment with parathyroid hormone significantly improves bone microarchitecture in postmenopausal osteoporotic women, David W. Dempster, Ph.D., reported in a poster at an international symposium sponsored by the National Osteoporosis Foundation.
The use of micro-CT supports research by Dr. Dempster, professor of clinical pathology at Columbia University, New York, and director of the regional bone center at Helen Hayes Hospital, West Haverstraw, N.Y., and his colleagues on the use of parathyroid hormone (PTH) as a bone builder.
The Treatment of Osteoporosis with Parathyroid Hormone (TOP) study, sponsored by Salt Lake City-based NPS Pharmaceuticals, included about 2,600 women treated daily with 100-mcg injections of PTH or a placebo for 18 months. In addition, all patients received 700 mg of calcium and 400 IU of vitamin D daily. The researchers obtained iliac crest biopsies from women in the PTH and placebo groups.
Based on the micro-CT data, the mean cancellous bone volume was significantly higher (45%) among ...
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Source: HighBeam Research, Imaging data from phase III study support parathyroid as bone...