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Monthly ibandronate superior to daily dosing.(Clinical Rounds)
CHICAGO -- A 2-year analysis has shown that once-monthly ibandronate provides bone mineral density increases in women with postmenopausal osteoporosis superior to those seen with the proven daily dose.
Previously reported 1-year results from the Monthly Oral Ibandronate in Ladies (MOBILE) study showed that once-monthly ibandronate (Boniva) was superior to daily dosing at the spine and total hip, and comparable in other areas. "At 2 years there was actually superiority in all areas of the hip, plus the spine, and the adverse event profile was very comparable at 1 and 2 years," Dr. Michael A. Bolognese, who headed the prospective, phase III study for Hoffmann-La Roche Inc., said in an interview.
Overall, 1,609 women, aged 55-80 years, with postmenopausal osteoporosis were randomized to oral ibandronate 2.5 mg daily or to one of three different monthly ibandronate doses: 150-mg, 100-mg, or two 50-mg doses on 2 consecutive days. The per-protocol population included 395 women in the 2.5-mg daily group and 396 in the 150-mg monthly ibandronate group.
In a per-protocol analysis, mean lumbar spine bone mineral density scores increased 4% from baseline in the daily group and 5% in the monthly group after 1 year, and 5% and 7%, respectively, after 2 years.
Similar increases were seen in the intent-to-treat population, Dr. Bolognese and his associates reported in a poster at the annual meeting of the American Association of Clinical Endocrinologists.
After 2 years, superior mean bone mineral density gains were seen at the hip with 150-mg monthly ibandronate when it was compared with daily dosing (total hip, 4% vs. 3%; femoral neck, 3% vs. 2%; trochanter, 6% vs. 4%).
There was no difference in the incidence of clinical fractures between the daily- and monthly-dose groups (26 vs. 29). The number of withdrawals due to adverse events was low and comparable for daily and monthly treatment (10% vs. 9%), reported Dr. Bolognese, who is in private practice in Bethesda, Md., and is a Roche speaker and grant recipient.
- Monthly ibandronate boosts BMD as well as daily dose.(Rx)
- Magazine article from: Internal Medicine News Splete, Heidi May 15, 2005 700+ words
WASHINGTON -- A monthly dose of oral ibandronate is at least as safe and as effective at increasing bone mineral density as a daily dose, according to data from a study of more than 1,200 post-menopausal women with osteoporosis. The Monthly Oral Ibandronate in Ladies (MOBILE) study, a multinational
- Once-monthly ibandronate holds its own at 2 years.(Rheumatology)
- Magazine article from: Internal Medicine News Jancin, Bruce August 1, 2005 700+ words
VIENNA -- Oral ibandronate at 150 mg once monthly showed continued impressive therapeutic efficacy in women with postmenopausal osteoporosis at the 2-year mark in the Monthly Oral Ibandronate in Ladies (MOBILE) trial, Pierre D. Delmas, M.D., said at the annual European congress of rheumatology.
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- Magazine article from: Women's Health Weekly July 2, 2009 700+ words
...bisphosphonate switched to 150 mg monthly ibandronate," scientists in the United States...or acid reflux after switching to monthly ibandronate. Further, >70% reported...satisfaction compared with baseline. Monthly ibandronate was generally well tolerated...
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...publish new data in the report 'Monthly ibandronate suppresses serum CTX-I within...Ibandronate was well-tolerated. Monthly ibandronate decreased serum CTX-I within 3...months, in women receiving once-monthly ibandronate, serum CTX-I remained suppressed...
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- Magazine article from: Women's Health Weekly August 13, 2009 700+ words
...patients were switched to 150 mg monthly ibandronate. At baseline and 6 months, patients...73.6% of patients preferred monthly ibandronate to weekly bisphosphonates. The...reported improved satisfaction with monthly ibandronate dosing." Bonnick and colleagues...
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- Magazine article from: Women's Health Weekly November 5, 2009 700+ words
...persistence with weekly risedronate and monthly ibandronate therapy. and methods: The IMS...patients taking weekly risedronate or monthly ibandronate over a 12-month period using three...drug availability were similar for monthly ibandronate and weekly risedronate dosing...
- FDA clears once-monthly osteoporosis therapy.(News)
- Magazine article from: OB GYN News Mechcatie, Elizabeth June 1, 2005 700+ words
...density (BMD) increases in the lumbar spine in patients on monthly ibandronate were significantly higher than in those on 2.5 mg of...copromoting ibandronate with Roche. The recommended dosage of monthly ibandronate is one 150-mg tablet taken on the same day once a month...
- Data from D. Kastelan et al provide new insights into osteoporosis.
- Magazine article from: Women's Health Weekly April 30, 2009 700+ words
...agreed to be enrolled were transferred from weekly to monthly ibandronate for the next 6 months. There was no washout period between...9% of patients stated improved quality of life with monthly ibandronate," wrote D. Kastelan and colleagues. The researchers...