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Fibromyalgia patients, siblings are extra sensitive to pain.(Clinical Rounds)
SAN ANTONIO -- Women with fibromyalgia and their siblings experience a generalized sensitivity to pain and lower levels of serum serotonin, according to new research.
These are the preliminary results of an ongoing study, said Dr. Laurence A. Bradley, who presented the study at the annual meeting of the American Pain Society.
A number of recent studies have shown that first-degree relatives of women with fibromyalgia have higher lifetime rates of major depressive and anxiety disorders, compared with first-degree relatives of those with rheumatoid arthritis. Other research has found that fibromyalgia and reduced pressure pain thresholds aggregate in families.
"Some studies show that female relatives of the fibromyalgia probands display higher rates of psychiatric disorders than do male relatives," said Dr. Bradley, who is a professor of medicine in the division of clinical immunology and rheumatology at the University of Alabama, Birmingham.
The goal of the current study was to measure pain sensitivity and blood serum levels of serotonin in female patients with fibromyalgia, sex-matched healthy controls, and the siblings of both the fibromyalgia probands and the controls.
It is unknown if the first-degree relatives of women with fibromyalgia exhibit the same pain sensitivity, explained Dr. Bradley, and if there are differences in the expression of serotonin in these relatives as well as in the patients. It is also unclear to what degree serotonin levels may mediate differences in pain sensitivity, not only in patients vs. controls but also in relatives of patients vs. relatives of controls.
Thus far, the current study has enrolled 49 families, and includes 16 probands with fibromyalgia; 5 male and 11 female proband siblings; 23 female, pain-free, control individuals; and 8 male and 15 female control siblings. All of the ...
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Source: HighBeam Research, Fibromyalgia patients, siblings are extra sensitive to pain.(Clinical...