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Methotrexate may cut oocyte yield after ectopic pregnancy.(Gynecology)
INDIAN WELLS, CALIF. -- Methotrexate is a safe and effective alternative to surgery for ectopic pregnancy; however, it may temporarily interfere with the success of fertility treatment, Dr. Janet McLaren reported at the annual meeting of the Pacific Coast Reproductive Society.
Significantly fewer oocytes were retrieved in cycles within 180 days of methotrexate-treated ectopic pregnancy, compared with cycles attempted beyond 180 days, in a study of 35 patients.
With patients serving as their own controls, the mean number of oocytes obtained in cycles in the first 6 months following methotrexate treatment of ectopic pregnancy was 7.8, compared to 10 during cycles performed before they received methotrexate.
Beyond 6 months, there was no reduction in the number of oocytes retrieved per cycle.
A slight decrease in endometrial thickness was also noted in the first 180 days following exposure to methotrexate, which targets rapidly dividing cells.
A total of 48 patients underwent fertility treatment following exposure to methotrexate in the chart review performed by Dr. McLaren and associates at Brigham and Women's Hospital and Harvard Medical School, both in Boston, and Stanford (Calif.) University Medical Center.
(Not all women underwent similar infertility procedures before and after methotrexate administration, and some lacked comparable pre- and post-methotrexate data, so not all subjects were included in the ...
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Source: HighBeam Research, Methotrexate may cut oocyte yield after ectopic pregnancy.(Gynecology)