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Despite avid interest in finding nonhormonal therapies for menopausal hot flashes, most alternative treatments have demonstrated only limited efficacy, and their safety remains in question, according to a systematic review of the literature.
Dr. Heidi D. Nelson and her associates at Oregon Health and Science University, Portland, compared all randomized, placebo-controlled trials of nonhormonal treatments for hot flashes with the efficacy and adverse effects of agents other than estrogens, progestins, progesterone, or androgens (JAMA 2006;295:2057-71).
A metaanalysis was conducted ...