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Investigational test screens for abnormalities in early pregnancy.(Obstetrics)
LOS ANGELES -- Scientists have developed a noninvasive "genetic Pap" test to screen for Down syndrome and other chromosomal abnormalities early in pregnancy.
The test analyzes trophoblast cells shed by the fetus and scraped from the cervix, investigator Moshe D. Fejgin, M.D., reported in an oral presentation at the annual meeting of the Society for Gynecologic Investigation.
Researchers found fetal cells in about 87% of nearly 500 samples from two studies. The test identified two cases of trisomy 21 and one case each of Turner's syndrome and Klinefelter's syndrome in 110 pregnancies, according to Dr. Fejgin of the Meir Medical Center in Kfar Saba, Israel.
Gender predictions were correct in 92% of samples, he said, with accuracy ranging from 89% in samples from women planning to complete their pregnancies and 94% from a group that chose termination. Dr. Fejgin described the test as 100% accurate in determining male gender.
"When you are running 80%-90% accuracy, it can be used as a diagnostic," Dr. Fejgin said.
He and his coinvestigators concluded that the "genetic Pap" has the ...
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Source: HighBeam Research, Investigational test screens for abnormalities in early...