Chemopreventive tretinoin dose can be increased: lower dose may not stave off BCCs and SCCs; irritation caused by higher dose proves transient.(Dermatologic Therapy)

Publication: Skin & Allergy News

Publication Date: 01-JUL-06

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COPYRIGHT 2006 International Medical News Group

PHILADELPHIA -- High-dose topical tretinoin is generally well tolerated for chemoprevention of basal and squamous cell carcinomas, Dr. Amy Geng said at the annual meeting of the Society for Investigative Dermatology.

Daily application of 0.1% tretinoin does cause some irritation, but this is generally mild, and tolerability tends to improve over time.

"Dermatologists tend to use 0.05% concentrations or lower, in an attempt to reduce the chances of irritation or other side effects. This is especially true for young patients with acne," said Dr. Geng of the department of dermatology at...

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