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Bcl-2 urine test for ovarian ca gets good results in pilot study.(Gynecology)
WASHINGTON -- Elevated levels of the Bcl-2 protein in urine were associated with 92% of ovarian cancers in a pilot study of 95 women, Patricia Kruk, Ph.D., said at the annual meeting of the American Association for Cancer Research.
"Ovarian cancer has the highest mortality rate among gynecologic malignancies," said Dr. Kruk. "It is usually detected in the very late stages, because we don't have very good detection systems and the women are generally asymptomatic."
The average amount of Bcl-2 in the urine of 36 women with ovarian cancer was more than 2 ng/mL, which was significantly greater--at least 10 times greater in most cases--than Bcl-2 levels in the urine of 21 healthy women and 38 women with benign gynecologic disease.
Urinary levels of Bcl-2 decreased up to 100% after patients ...
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