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COPYRIGHT 2006 International Medical News Group
BETHESDA, MD. -- Variations in the activity of the primary enzyme involved in nicotine metabolism may largely explain lower smoking levels and lung cancer rates found in slow metabolizers, Rachel F. Tyndale, Ph.D., said at the annual meeting of the American Society of Preventive Oncology.
Lowering the activity of the enzyme CYP2A6 in people with normal enzyme activity or with multiple copies of the gene for the enzyme may help in quitting smoking or reducing exposure to carcinogens in tobacco smoke, said Dr. Tyndale, professor of pharmacology at the University of Toronto.
CYP2A6, part of the cytochrome P450 family of liver enzymes, removes about 80%...
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