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COPYRIGHT 2006 International Medical News Group
The second part of this three-part series examines the safety of drugs used to treat several gastrointestinal diseases that cause significant morbidity in pregnant women.
* Helicobacter pylori infection: Several studies have linked this infection to severe nausea/vomiting of pregnancy. Eradication regimens involve dual, triple, or quadruple therapy, typically for 2 weeks, combining one or two anti-infectives and an antisecretory agent. Bismuth and ranitidine bismuth citrate are sometimes added to the regimen.
If clinically acceptable, the best course is to delay therapy until after the first trimester. Of the four anti-infectives used (amoxicillin, clarithromycin, metronidazole, and tetracycline), only tetracycline clearly causes developmental toxicity, but the carcinogenic potential of metronidazole has not...
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