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'Vanishing twin' may hurt outcomes in IVF singletons.(News)
COPENHAGEN -- The poorer obstetric outcome of singletons conceived through in vitro fertilization, compared with those who are naturally conceived, may be partially explained by the phenomenon of the "vanishing twin"--the disappearance of at least one gestational sac after the documentation of fetal activity, according to Danish researchers.
"One in 10 IVF singletons originates from a twin gestation, and this could be one of the major causes for the higher risk of adverse obstetric outcomes in IVF singletons," said Anja Pinborg, M.D., who presented her study at the annual meeting of the European Society for Human Reproduction and Embryology.
She speculated the toxic environment created by the demise of one twin could be responsible for compromising the health of the survivor. "This is yet another argument in favor of single embryo transfers."
There is already strong evidence that, among naturally conceived twins, the death of one twin in utero is associated with as much as a 10-fold increase in the risk of cerebral palsy for the surviving twin, said Dr. Pinborg, of the University of Copenhagen.
In IVF pregnancies, the spontaneous loss of at least one gestational sac has been correlated with a shorter pregnancy and lower birth weight of any surviving fetus (Obstet. Gynecol. Clin. North. Am. 2005;32:17-27).
In another, very recent Danish study, investigators proposed that even the demise of extra embryos after IVF and embryo transfer could pose an obstetric risk. The investigators noted that among more than 9,000 children conceived through IVF, there was an increased incidence of cerebral palsy in pregnancies for which the number of children born was less than the number of embryos originally transferred (Hum. Reprod. 2005;[Epub ahead of print; PMID 15890728]).
In Dr. Pinborg's study, she and her associates retrospectively analyzed 9,557 children conceived through IVF at 11 clinics. The cohort included 5,237 singletons, 3,678 twins, and 642 singleton survivors of a vanishing-twin pregnancy. To ...
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VIENNA, Jul 03, 2002 A study presented Wednesday suggests single fetuses conceived from in vitro fertilization are at greater risk for miscarriage than twins created from fertility treatment, contradicting the mainstream belief that single pregnancies have the best odds of success. Researcher Dr.
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MONTREAL -- A history of a vanishing twin appears strongly associated with adverse...Friedman said this was the first vanishing twin study to control for maternal variables...37 weeks' gestation, was higher in vanishing-twin pregnancies, compared with single...
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...in vitro fertilization (IVF) singletons originates from a twin gestation...assess the impact of a 'vanishing twin' on first trimester combined...cases of pregnancies with a vanishing twin were identified. As control...lt; 9, EVT) or late vanishing twin (gestational week ...
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...is to examine pubertal development in 8-18-year-old IVF singletons and controls born from subfertile parents who attended one Dutch fertility clinic were included. IVF singletons and controls born from subfertile parents who attended one...
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...higher mean birthweight compared with fresh singletons, in ICSI and IVF, reaching significance when all cryo (ICSI plus IVF) singletons were considered. Low birthweight rate according to multiplicity was comparable between the fresh and the cryo groups...
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...injection, including 46 survivors of vanishing twin syndrome (study group) and 92 matched...gestational age for survivors of the vanishing twin syndrome was found," wrote O. Shebl...weight is lower for survivors of the vanishing twin syndrome: a case-control study...
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...may result from poor implantation or may be caused by a "vanishing twin"--the intrauterine demise of any additional embryos...the controls (2.39 vs. 2.18), and the incidence of vanishing twin was significantly higher in the bleeding group (8.7...
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The Vanishing Twin Through Dec. 8 Chicago Filmmakers, 1543 W. Division Tickets...M" and "The Scarlet Letter"). The latest offering is "The Vanishing Twin," written and directed by Bruce Norris and billed as a "gothic...
