AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Metaanalysis: aspirin below 100 mg/day is safest; Researchers were surprised to find that bleeding risk climbed sharply with doses in moderate range.(Clinical Rounds)
ORLANDO, FLA. -- When it comes to prescribing daily aspirin for the prevention or treatment of vascular events, the lowest risk of bleeding complications in a new metaanalysis involving more than 192,000 patients was seen at dosages that were less than 100 mg/day, Victor L. Serebruany, M.D., reported during the annual meeting of the American College of Cardiology.
The most surprising finding in this massive metaanalysis was not that lower aspirin doses are safer--"You don't need to be a rocket scientist to realize that," he said--but rather, that the bleeding risk climbed dramatically with dosages even in the moderate range of 100-200 mg/day. The analysis involved 31 randomized controlled trials published since 1988.
"We do not know if 75 mg/day of aspirin is better or worse than 325 mg in terms of efficacy, because there has been no direct comparative trial. However, now we know for sure that the lower the dose, the less the bleeding risk.... The absolutely practical, simple lesson is, if you are not sure that efficacy is actually different, use as low a dose as possible," stressed Dr. Serebruany, owner of HeartDrug Research, LLC, of Towson, Md.
Of the 31 trials included in the metaanalysis, 9 featured low-dose aspirin arms. Eight examined the impact of moderate-dose aspirin, defined by Dr. Serebruany as 100-200 mg/day. Nineteen had high-dose aspirin arms, involving daily doses greater than 200 mg.
The rate of major bleeding was around 1.5% in patients on low- or moderate-dose aspirin, rising to more than 5% in the high-dose ...
- Lifesaving Benefits of Low-Dose Aspirin Therapy Maintained With Naproxen Sodium.
- Press release article from: PR Newswire November 7, 2007 700+ words
...criteria were given 81 mg of enteric- coated, low-dose aspirin once daily. After...continued on 81 mg of enteric-coated, low-dose aspirin once daily...were given 81 mg of enteric-coated, low-dose aspirin once daily plus...
- Lifesaving Benefits of Low-Dose Aspirin Therapy Maintained with Naproxen Sodium.
- Press release article from: PR Newswire November 9, 2007 700+ words
...criteria were given 81 mg of enteric- coated, low-dose aspirin once daily. After...continued on 81 mg of enteric-coated, low-dose aspirin once daily...were given 81 mg of enteric-coated, low-dose aspirin once daily plus...
- Low dose aspirin for preventing and treating pre-eclampsia.(Statistical Data...
- Magazine article from: British Medical Journal July 31, 1999 700+ words
...of the start of treatment with low dose aspirin is important. The studies consistently...effective at higher doses (100-150 mg/day) than at lower doses (50...Schemoer M. A meta-analysis of low dose aspirin for the prevention of intrauterine...
- Low-dose aspirin for heart protection: how low should a safe dose be?
- Newspaper article from: HealthFacts Napoli, Maryann June 1, 2007 700+ words
...studies, ranged from 30 mg/daily to 650 mg/twice daily. Though...Americans take low-dose aspirin to prevent cardiovascular...associated with low-dose aspirin. Bottom line: The conclusion...S.--between 81 mg and 325 mg. A baby aspirin...
- Low-dose Aspirin and Endoscopic Gastric and Duodenal Ulcer Rates in Users of...
- Magazine article from: Internal Medicine Alert July 29, 2006 700+ words
Low-dose Aspirin and Endoscopic Gastric...been reported with low dose aspirin administration in the past...selective NSAIDs plus low-dose aspirin. The present 39-center...group, 92 received 325 mg aspirin (ASA) plus placebo...
- PPI with low-dose aspirin cuts ulcer formation 71%.(News)
- Magazine article from: Internal Medicine News Jancin, Bruce November 1, 2006 700+ words
...patient on low-dose aspirin, 'If you choose...prophylactic low-dose aspirin because of preexisting...Nexium) at 20 mg once daily or placebo...definitely say go for 100 mg or less," he added...long-term, low-dose aspirin. "By the time you...
- AstraZeneca Submits NDA for Low Dose Aspirin/Esomeprazole Combination Product.
- Press release article from: PR Newswire May 4, 2009 700+ words
...for the risk reduction of low dose aspirin-associated gastric and/or...gastric ulcers.(1) Low-dose aspirin is the mainstay in the prevention...ulcers in patients who take low dose aspirin (75-325 mg continuously during the study...
- Low-dose aspirin therapy linked to GI bleeding: physicians' health...
- Magazine article from: Family Practice News Worcester, Sharon July 15, 2003 700+ words
...Long-term low-dose aspirin therapy is a risk...dose of one 325-mg tablet every other...the use of low-dose aspirin for reducing cardiovascular...patients took 325 mg of aspirin every...standard for low-dose aspirin therapy involves lower doses (usually 75 mg ...
- Low-dose aspirin offers adults inflammation protection.
- Magazine article from: AORN Journal February 1, 2005 700+ words
...clinical trial that Low-dose aspirin (ie, 81 mg) triggers the human body...mg), medium (ie, 325-mg), or high (ie, 650-mg) dose of aspirin for eight...beneficial impact of low-dose aspirin and its anti-inflammatory...
- Low-dose aspirin does not slow cognitive decline in older women.(What's New in...
- Newspaper article from: The Brown University Geriatric Psychopharmacology Update September 1, 2007 700+ words
...assigned to low-dose aspirin over a treatment...determine whether 100 mg aspirin given on...J, et al.: Low dose aspirin and cognitive function...investigating aspirin 100 mg every other day or...treatment with low-dose aspirin does not provide...
