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Consider renal effects of high-protein diets.(Clinical Rounds)
WASHINGTON -- The renal effects of high-protein diets pose a strong risk of harm in patients with chronic kidney disease, Allon Friedman, M.D., said at a meeting sponsored by the National Kidney Foundation.
Chronic kidney disease is often silent, so he recommends obtaining a serum creatinine measurement and a urinary dipstick test for proteinuria in all patients considering a high-protein diet for weight loss.
Those with a glomerular filtration rate less than 60 mL/min should be advised against a high-protein diet, said Dr. Friedman of Indiana University in Indianapolis.
Regardless of kidney function, protein intake increases glomerular filtration rate and renal blood flow by as much as 100% from baseline.
Over time, a high-protein diet appears to increase kidney volume and weight.
Studies suggest that high-protein diets increase urinary protein excretion in people with normal and in those with diminished kidney function, Dr. Friedman said.
High-protein diets are intended to induce ketosis by limiting carbohydrate intake. Increased ketone levels lead to increased sodium output, which in turn ...
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