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ANAHEIM, CALIF. -- Long-term use of nonsteroidal anti-inflammatory drugs results in a 50% reduction in oral cancer in heavy smokers, according to a population-based, nested, case-control study, Jon Sudbo, M.D., reported at the annual meeting of the American Association for Cancer Research.
But despite this significant reduction in oral cancer--which carries a 5-10 year mortality rate of about 50%--there was no overall decrease in mortality in the cohort.
Further investigation by Dr. Sudbo, of the University of Oslo (Norway), and his colleagues revealed that the decrease in oral cancer was apparently offset by a doubling in the risk of cardiovascular death among long-term NSAID users.
The study combined data from the Norwegian Institute of Public Health and the Norwegian Cancer Registry. From approximately 123,000 individuals, the investigators identified 9,241 who had smoking histories of 15 pack-years or more.
Of those, the researchers identified 454 diagnosed with squamous cell carcinoma of the oral ...