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Pesticides linked to higher risk of Parkinson's.(Clinical Rounds)
MIAMI BEACH -- Exposure to pesticides or herbicides appears to raise the risk of Parkinson's disease by 70%, Alberto Ascherio, M.D., said at the annual meeting of the American Academy of Neurology.
The study--the largest prospective analysis of pesticide exposure and Parkinson's--doesn't contain details about specific compounds, but it does suggest even casual exposure could increase the risk of the disease, Dr. Ascherio said in an interview.
"We also found this relationship in people who were ... not occupationally exposed to the chemicals," said Dr. Ascherio.
This suggests even low levels of exposure could be significant. Dr. Ascherio stressed more studies are needed to confirm which pesticides could be the most toxic.
Dr. Ascherio based his study on the American Cancer Society Cancer Prevention Study-II Nutrition Cohort (ACS CPS-II) data. The study included more than 160,000 adults, aged 50-79 years, who were recruited in 1992.
The participants had filled out a pesticide exposure survey 10 years before their enrollment. In addition to asking about pesticide exposure, the survey also asked subjects to report exposures to asbestos; acids; solvents; coal dust and tar; diesel and gasoline fumes; formaldehyde; dyes; textile fibers and dust; wood dust; and x-rays or other radiation.
Of the entire cohort, 413 developed Parkinson's disease between 1992 and 2000. Among environmental exposures, the only significant association was pesticide or herbicide exposure, which increased the risk of disease by 70%, said Dr. Ascherio, of the departments of nutrition and epidemiology at the Harvard School of Public Health, Boston.
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