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HPV testing may help manage LSIL.(Gynecology)
VANCOUVER, B.C. -- Low-grade squamous intraepithelial lesions were likely to regress in women older than 30 years who were not infected with types of human papillomavirus associated with a high risk for cervical cancer, a longitudinal study found.
Of 412 women with untreated low-grade squamous intraepithelial lesions (LSIL), only women who tested positive for high-risk human papillomavirus (HPV) developed cervical intraepithelial neoplasia grades 2 or 3 (CIN 2/3) in 2 years of follow-up, Christine C. Clavel, Ph.D., said at the 22nd International Papillomavirus Conference.
HPV testing is approved in the United States to help triage women with Pap results showing atypical squamous cells of undetermined significance, or as an adjunct to Pap smears for screening women older than age 30.
The study suggests that it also might be helpful by allowing a longer interval between follow-ups in women with LSIL and a negative HPV test, said Dr. Clavel of the University of Reims (France) Hospital Center.
At baseline, 87% of the 412 women and 80% of those older than 35 years tested positive for high-risk HPV types. Colposcopy and biopsies found 21 cases of CIN 2/3 at baseline and an additional 12 cases ...
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