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SAN FRANCISCO -- An investigational testosterone patch applied twice weekly improved sexual functioning in as little as 4 weeks in surgically menopausal women, Sheryl Kingsberg, Ph.D., reported in a poster presentation at the annual meeting of the American College of Obstetricians and Gynecologists.
Two randomized, double-blind, placebo-controlled studies together involved 1,095 women aged 20-70 years with hypoactive sexual desire disorder (HSDD) an average of 9 years following oophorectomy. The women applied patches delivering 300 mcg/day of testosterone or placebo, twice a week for 24 weeks.
Patients kept a log of their sexual activity and completed questionnaires related to their sexual desire and distress, stated Dr. Kingsberg of Case Western Reserve University in Cleveland, and her coauthors, including an employee of Procter & Gamble Pharmaceuticals. The company plans to market the Intrinsa testosterone transdermal system pending approval by the Food and Drug Administration.
At the end of the 24 weeks, women on a placebo patch experienced an increase ...