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Urge incontinence treated with flexible dosing of oxybutynin.(Gynecology)

OB GYN News

| July 01, 2005 | Finn, Robert | COPYRIGHT 2005 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

SAN FRANCISCO -- Almost half of patients on flexible-dosing schedules of extended-release oxybutynin for urge incontinence chose a dose of more than 10 mg/day, the level employed in two fixed-dose trials of the medication, Peter K. Sand, M.D., and Scott A. MacDiarmid, M.D., reported in a poster presentation at the annual meeting of the American College of Obstetricians and Gynecologists.

In a combined analysis of 368 patients from three clinical trials employing flexible dosing schedules of 5-30 mg/day, 47% of participants chose a final dose of 15, 20, 25, or 30 mg/day.

At all selected final doses of oxybutynin, 77%-83% of the patients reportedly achieved a reduction of at least 70% in the number of urge in continence episodes, according to Dr. Sand of ...

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