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Metformin, reduced-calorie diet improve CV risk in PCOS patients.(Gynecology)
WASHINGTON -- Metformin combined with a reduced-calorie diet reduced cardiovascular risk in a study of 791 women with polycystic ovary syndrome, Mofiz Haque, M.D., reported in a poster presented at the Clinical Research 2005 meeting.
The metformin-diet (MET-D) combination was effective in reducing weight, triglycerides, and LDL cholesterol, while increasing HDL cholesterol, reported Dr. Haque of the cholesterol center at the Jewish Hospital, Cincinnati, and his colleagues.
At baseline, the women had a median weight of 95 kg; 15% were overweight, 46% were obese, and 29% were severely obese. At baseline, the mean triglyceride level was 108 mg/dL, LDL cholesterol was 116 mg/dL, and HDL cholesterol was 46 mg/dL.
Women with a BMI less than 25 kg/[m.sup.2] were given a 2,000-calorie per day diet, and those with a BMI of 25 kg/[m.sup.2] or higher were given a 1,500-calorie diet. Each diet included 26% of calories from protein and 44% from carbohydrate, they noted at the meeting, sponsored by the American Federation for Medical Research.
Overall, metformin targeted to 2,500 mg/day in combination with dietary restriction was associated with significant reductions in weight, triglycerides, LDL ...
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