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Acne drug trial offers long-term results.(Clinical Rounds)

OB GYN News

| September 01, 2005 | Bates, Betsy | COPYRIGHT 2005 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

MAUI, HAWAII -- An open-label trial of adapalene gel 0.3% offered a rare long-term look at efficacy beyond the standard duration of most clinical acne medication trials.

"Most of the trials that we do with retinoids or topical acne treatments are for 12 weeks, and you often wonder what happens to the patient after that 12 weeks," Diane M. Thiboutot, M.D., said at an annual Hawaii dermatology seminar sponsored by the Skin Disease Education Foundation.

A 1-year, open-label, 277-patient trial sponsored by Gal-derma Laboratories found that lesion counts continue to improve beyond the 50%-55% reduction from baseline seen at 12 weeks. By 52 weeks, lesion counts had declined 80% from baseline.

Dryness was reported by ...

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