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NAT2 genotype, red meat tied to increase in colorectal ca risk.(Clinical Rounds)
CHICAGO -- High intake of red meat has been linked to increased risk of colorectal cancer in many studies, and a new study has found a possible reason.
NAT2 genotype appears to activate carcinogenic heterocyclic amines produced in cooked red meat and in cigarette smoke, the investigators reported at the annual Digestive Disease Week.
Using data from nearly 33,000 women enrolled in the prospective Nurses' Health Study, Andrew Chan, M.D., and his coauthors examined the risk of incident colorectal cancer according to NAT2 genotypes, meat intake, and smoking. They matched 183 women with colorectal cancer to 443 controls (Int. J. Cancer 2005;115:648-52).
They found that the acetylator genotype alone did not significantly increase cancer risk. However, women with rapid acetylator genotypes had a markedly increased risk of colorectal cancer if they consumed more than half a serving a day of beef, pork, or lamb, he reported. Their risk was three times that of women who ate less red meat; if ...
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...associations of high red meat consumption with increased colorectal cancer, but summary...association between red meat consumption and colorectal cancer; a third reported...mechanisms by which red meat might cause colorectal cancer. * ...
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...High intake of red meat has been linked to increased risk of colorectal cancer in many studies...raise the risk of colorectal cancer. "We definitely...who consumed less red meat decreased their colorectal cancer risk," Dr. Chan...
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...family history of colorectal cancer or colorectal...diet high in red meat, - Sedentary...Tobacco use. Colorectal cancer typically starts...their risk of colorectal cancer by eating a...consumption of fat and red meat, having a physically...
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...important components of colorectal cancer prevention. The amount...factors associated with colorectal cancer. Experts found that...limited consumption of red meat, helps reduce the risk of colorectal cancer. It also is recommended...
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...of developing colorectal cancer. There is convincing...protein, red meat, carbohydrates...increases risk of colorectal cancer. Previous studies...LOWER RISK OF COLORECTAL CANCER Hyperinsulinemia...saturated fat, red meat and refined...
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...is likely that red meat other than beef...major cause of colorectal cancer. There was a...have a lot of red meat in diet and still...a low risk of colorectal cancer if one has high...eats a lot of red meat, takes no supplement...calcium and develops ...
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- Newspaper article from: Seattle Post-Intelligencer (Seattle, WA) Phinney, Susan March 26, 2007 700+ words
...screening test for colorectal cancer will be available...percent of risks for colorectal cancer are from environmental...A diet heavy with red meat, but low in fiber...for example. When colorectal cancer metastasizes it usually...
