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Calcitonin spray may preserve trabecular bone architecture.(Gynecology)
BETHESDA, MD. -- Calcitonin nasal spray appears to preserve trabecular bone microarchitecture at the distal radius without substantially altering bone mineral density, Charles H. Chestnut III, M.D., reported during a meeting on bone quality.
In a 2-year, randomized, double-blind trial involving 91 women with an average age of 67 years, high-resolution MRI analysis of the distal radius showed that calcitonin nasal spray preserved significantly more trabecular bone architecture than placebo.
Calcitonin's effects included preservation of the volume, number, spacing, and thickness of trabecular bone, Dr. Chestnut wrote in a poster presentation at the meeting, which was sponsored by the National Institute for Arthritis and Musculoskeletal and Skin Diseases and the American Society for Bone and Mineral Research.
Trabecular bone microarchitecture was significantly preserved--if not reinforced--in calcitonin patients, compared with placebo patients, despite loss in bone mineral density (BMD) at the distal radius or lumbar spine during the same period, Dr. Chestnut said.
In placebo patients, the number of trabeculae declined slightly at those sites even if the women had gained BMD.
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