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Study ties long-term use of acid suppressors to fracture risk.(Gynecology)
CHICAGO -- Long-term use of proton-pump inhibitors, histamine[.sub.2]-receptor antagonists, and other acid suppressors increases the risk of hip fracture, Yu-Xiao Yang, M.D., reported at the annual Digestive Disease Week.
Physicians turning to a combination of NSAIDs and proton-pump inhibitors (PPIs) in place of cyclooxygenase-2 (COX-2) inhibitors should be aware of this effect in patients who are at increased risk of osteoporosis, but they should not deny this therapy to patients with appropriate indications, said Dr. Yang of the division of gastroenterology at the University of Pennsylvania, Philadelphia.
PPIs interfere with calcium absorption, leading to an increased risk of hip fracture.
"Do patients with more than 1 year of PPI therapy have more hip fractures? Up until now, there has been no epidemiological study to address this," Dr. Yang said.
His conclusions came from a retrospective cohort study of 518,096 patients older than 40 years who were included in the U.K. General Practice Research Database between May 1987 and April 2002. Of these, 47,631 had more than 1 year of exposure to a PPI; the remaining 470,465 patients had no exposure to either a PPI or histamine[.sub.2]-receptor antagonist (H2RA).
By looking at complete prescription information and validated hip fracture reports, the researchers discovered that ...
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