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ICSI fathers may transmit genetic disease risk.(Gynecology)
SAN DIEGO -- Infertile men undergoing intracytoplasmic sperm injection display an elevated rate of genetic variations that may predispose them to pass on traits associated with neurodegenerative diseases, according to a study presented at the annual meeting of the Endocrine Society.
"This technique overcomes tremendous genetic barriers to reproduction and allows men with genetic disorders to achieve a pregnancy. It is therefore our concern that they will transmit these diseases to offspring," said Francesca Gordon, a research associate at Baylor College of Medicine, Houston.
Ms. Gordon, Dolores J. Lamb, Ph.D., and their associates at Baylor and Monash Medical Center, Melbourne, obtained DNA samples from 647 infertile men whose partners were undergoing in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI) in Houston and Melbourne and 369 normal controls from the same cities.
Polymerase chain reaction was used to analyze the lengths of triplet repeat tracts, also known as microsatellites, for three alleles associated with neurodegenerative disease: spinocerebral ataxia type 1 (SCA1), spinocerebral ataxia type 2 (SCA2), and dystrophia myotonica.
Several triplet repeat diseases such as Kennedy syndrome and myotonic dystrophy are associated with infertility.
The researchers hypothesized that expanded (normal, but unstable) microsatellite lengths associated with other triplet repeat diseases might be more common in infertile men, potentially putting at risk their children conceived through ICSI.
Ms. Gordon explained that there is a spectrum of repeat triplet lengths for each allele, ranging from normal to expanded-normal--a pattern that might pose a "pool of instability for future generations"--to a long expanse of triplet repeat tracks, associated with the development of symptoms. The ...
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