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Vaginal flora may affect HIV RNA concentrations.(Gynecology)
CHARLESTON, S.C. -- Certain vaginal isolates affect the quantity of HIV RNA in cervicovaginal lavage, a study suggests.
Hydrogen peroxide-producing lactobacilli, for example, were associated with a significant decrease in cervicovaginal lavage (CVL) HIV RNA concentrations, and Trichomonas vaginalis, Prevotella bivia, and Mycoplasma hominis. Other anaerobes were associated with increases in CVL HIV RNA concentrations, Jane Hitti, M.D., reported at the annual meeting of the Infectious Diseases Society for Obstetrics and Gynecology.
Factors affecting the HIV RNA concentrations are important, because genital viral load is an important determinant of sexual and perinatal HIV transmission, she noted.
For the study, 38 HIV-positive women completed 163 study visits. Vaginal cultures, CVL, and plasma were collected at each visit for HIV RNA quantiation. Of 163 CVL samples, 95 had detectable HIV RNA, and the levels correlated significantly with plasma HIV RNA levels, said Dr. Hitti of the University of Washington, Seattle.
After adjustment for log plasma HIV RNA, the log ...
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