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Study links chlamydia, abnormal uterine bleeding.(Gynecology)
CHARLESTON, S.C. -- Chlamydia trachomatis may play more of a role in abnormal uterine bleeding than previously recognized, Miklos Toth, M.D., reported at the annual meeting of the Infectious Diseases Society for Obstetrics and Gynecology.
Although many women with abnormal uterine bleeding have endometritis that is associated with silent pelvic inflammatory disease (PID), and C. trachomatis is the most important pathogen in the etiology of silent PID, the histologic features of chlamydia endometritis and the relationship between C. trachomatis and abnormal uterine bleeding have not been well described, said Dr. Toth of Lenox Hill Hospital, New York.
To better define these factors, he studied 92 archived endometrial biopsy specimens from premenopausal women with abnormal uterine bleeding and/or endometritis. Of these, 48% tested positive for C. trachomatis by species-specific monoclonal antibody against the major outer membrane protein (MOMP).
The specimens also were tested for histopathology associated with inflammation, and associations were noted between C. trachomatis (defined as a positive MOMP-specific ...
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