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CHARLESTON, S.C. -- Oral and vaginal metronidazole appear to have comparable efficacy for the treatment of bacterial vaginosis in low-risk pregnant women, but neither is optimal for prevention of infectious complications at delivery, Jane Hitti, M.D., reported during the annual meeting of the Infectious Diseases Society for Obstetrics and Gynecology.
In a double-blind, placebo-controlled study of 126 women with bacterial vaginosis who were randomized at or before 20 weeks' gestation to receive either oral or vaginal metronidazole, the treatment failure rate was similar for both groups (29% for oral administration vs. 35% for vaginal administration), Dr. Hitti of the University of Washington, Seattle, reported in a poster presentation at the meeting.
The oral administration group received 250 mg of metronidazole three times daily for 1 week; the vaginal administration group was treated with 5 g of 0.75% gel twice daily for 5 days. Treatment failure was defined as persistent BV at 4 weeks after ...