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CHARLESTON, S.C. -- Oral valacyclovir was the most economically favorable treatment choice for the prevention of intrapartum herpes transmission in a recent analysis.
The clinical outcomes and costs of the three strategies, including oral valacyclovir, oral acyclovir, and no prophylaxis, were compared using a decision analysis model in a hypothetical cohort of 1 million women with recurrent herpes infection. All strategies included cesarean section for patients with active lesions during labor, Monique G. Lin, M.D., of the University of Alabama, Birmingham, and her colleagues reported in a poster at the annual meeting of the Infectious Diseases Society for Obstetrics and Gynecology.
The valacyclovir model included 500 mg given twice daily beginning at 36 weeks' gestation; the oral acyclovir model included 200 mg given four times daily beginning at 36 weeks' gestation.
The investigators used the literature and "local sources" to determine baseline ...