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Vitamin D often low in obese children, teens.(Clinical Rounds)
OLD GREENWICH, CONN -- Vitamin D deficiency, sometimes quite severe, is common in obese adolescents, according to a recent study by Dr. Margarita Smotkin-Tangorra and colleagues at Maimonides Medical Center, N.Y.
Speaking at a meeting of the Eastern Society for Pediatric Research, Dr. Smotkin-Tangorra, of the department of pediatric endocrinology and diabetes at the medical center, said that 55% of a cohort of 217 obese children and adolescents were deficient in serum 25-hydroxyvitamin D (25-OHD), with blood levels of less than 20 ng/mL; 22% were severely deficient, with serum levels below 10 ng/mL.
Though there are published reports showing correlations between vitamin D deficiency and obesity in adults, there are no prior studies in children or teens. "We know vitamin D deficiency is prevalent in all age groups, including healthy adolescents. In obese adults, we know that it correlates with insulin resistance, progression to diabetes mellitus, metabolic and endocrine problems, and increased risk of cancer. We wanted to see if there were similar correlations in obese kids," she told attendees at the meeting, cosponsored by Children's Hospital of Philadelphia.
The study group included 118 females and 99 males, ranging in age from 7 to 18 years, and with a mean BMI of 32.2 kg/[m.sup.2]. In addition to measuring 25-OHD, the researchers also measured blood pressure, total cholesterol, LDL, HDL, triglycerides, liver enzymes, thyroid hormones, fasting insulin, and fasting blood glucose.
They found strong correlations between low vitamin D level and elevated BMI, increased systolic blood pressure, lower HDL, and lower alkaline phosphatase. The correlation between vitamin D status and BMI was particularly striking. Those patients who were vitamin D deficient had a mean BMI of 36.2, compared with a mean of 30.6 among patients whose vitamin D levels were sufficient. The association with systolic hypertension was also noteworthy; vitamin D-deficient patients had a mean systolic blood pressure of 117 mm Hg, while those with sufficient vitamin D had a mean systolic blood pressure of 111 mm Hg. Mean HDL ...
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Source: HighBeam Research, Vitamin D often low in obese children, teens.(Clinical Rounds)