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Bleeding, pathogens combined increase risk of preterm birth.(Obstetrics)
MIAMI BEACH -- Unexplained vaginal bleeding and fetal exposure to oral pathogens have been linked individually with spontaneous preterm birth, and new data suggest the presence of both is associated with greater risk than either alone.
Of 660 pregnancies analyzed, 229 (35%) demonstrated fetal exposure to oral pathogens. Pregnancies that demonstrated such exposure were more likely to be in white women, women who had symptomatic bacterial vaginosis, and women who experienced vaginal bleeding, which was the most significant variable associated with oral pathogen exposure (adjusted risk ratio 1.6).
A total of 51 women (8%) in this planned secondary analysis of the Oral Conditions and Pregnancy Study--a prospective observational study of oral health and pregnancy outcomes--delivered before 35 weeks' gestation, Dr. Kim Boggess reported at the annual meeting of the Society for Maternal-Fetal Medicine.
When women with vaginal bleeding were stratified according to whether fetal exposure to oral pathogens occurred, preterm birthrates were significantly higher in those with both factors. Preterm birth occurred in 30% of those with both factors, compared with 8% in those with only vaginal bleeding, 9% of those with only oral pathogen exposure, and 6% of those with neither.
After adjustment for age, race, prior preterm birth, prior elective or spontaneous abortion, bacterial vaginosis, and enrollment weight, the differences remained. ...
- Bleeding, oral pathogens linked to preterm birth.(Women's Health)
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