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Plan B has limited effect on bleeding patterns.(Gynecology)
BOSTON -- A single dose of Plan B (levonorgestrel) alters the timing and duration of the menstrual period that immediately follows emergency contraception, according to a new study. Taken early in the cycle, it causes the menstrual period to commence earlier than usual. Taken late in the cycle, it prolongs the next menstrual period.
But intermenstrual bleeding is uncommon, and menstrual timing resumes its normal pattern with the second cycle said coauthor James Trussell, Ph.D., professor and director of the Office of Population Research at Princeton University. Dr. Trussell presented the research at a conference on contraceptive technology sponsored by Contemporary Forums. The paper was simultaneously published in the journal Contraception (2006;73:376-81).
The study may help to settle an ongoing debate about the clinical significance of bleeding after the use of emergency contraceptive pills (ECPs). Several previous studies have suggested that ECPs provoke intermenstrual bleeding. The new study's message--that Plan B merely hastens the end of a cycle and that this effect is short-lived--will be reassuring to many women.
For women with late menses, however, the study suggests a pregnancy test may be in order.
Researcher Dr. Elizabeth G. Raymond, of Family Health International in Research Triangle Park, N.C., with Dr. Trussell and colleagues asked 113 women to maintain daily bleeding diaries for 10 weeks after receiving a single dose of 1.5 mg of levonorgestrel.
The women, who were patients at a Planned Parenthood clinic in Boston, had no known risk factors for bleeding abnormalities.
Though Plan B dosing approved by the Food and Drug Administration consists of two 0.75-mg pills taken 12 hours apart, the International Consortium for Emergency Contraception currently recommends the 1.5-mg single-dose regimen. Research since Plan B's 1999 approval suggests that the single-dose regimen is safe and effective (Lancet 2002;360:1803-10; Contraception 2002;66:269-73).
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