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Family history of coronary disease boosts coronary risk.(Clinical Rounds)
NEW ORLEANS -- Sisters of patients with early coronary disease had an unexpectedly high prevalence of coronary artery disease themselves in a study with 102 apparently healthy women without diabetes.
The actual presence of coronary disease in these women far exceeded their estimated risk calculated by the Framingham risk formula, the major tool used in the United States to assess a person's 10-year risk of having a major coronary event. Because of this disparity between estimated risk and actual disease in women with a family history of coronary disease, such women "likely warrant being considered for noninvasive screening for subclinical atherosclerosis," Erin D. Michos, M.D., said at the annual scientific sessions of the American Heart Association.
The noninvasive screening could consist of measuring the woman's serum level of C-reactive protein, or measuring coronary calcium with CT, said Roger S. Blumenthal, M.D., director of preventive cardiology at Johns Hopkins Hospital in Baltimore and a coinvestigator in the study.
The 102 women in the study were sisters of 71 probands who had been identified with coronary artery disease when they were younger than ...
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