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Studies offer support for low-carbohydrate diets.(Clinical Rounds)

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| January 01, 2005 | McNamara, Damian | COPYRIGHT 2005 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

ORLANDO, FLA. -- Low-carbohydrate ketogenic diets promote greater weight loss and improve certain serum lipids, compared with low-calorie diets, according to a literature review.

Low-carbohydrate strategies for weight loss, such as the Atkins or South Beach diets, are very popular despite a relative scarcity of scientific data to support their use. Since 2003, six published randomized, controlled trials have compared these diets with more traditional low-calorie approaches for weight control.

Researchers followed outpatients for 3 months to 1 year and compared baseline weight and serum lipids with follow-up values. All participants received recommendations for low-fat intake and regular exercise and attended group meetings.

"There was greater weight loss with the low-carb diet in all these trials," Eric C. Westman, M.D., said at a symposium on obesity sponsored by the American Society of Bariatric Physicians.

In five of these trials--which comprised from 30 to 132 participants--the average weight loss in low-carbohydrate diet groups ranged from 5.1 kg to 12 kg compared with an average weight loss of 1.9-6.5 kg in the low-calorie diet groups.

Differences were less pronounced in the sixth, most recent trial (Ann. Intern. Med. 2004;140:769-77). It may have been because the low-carbohydrate group received nutritional supplements according to the Atkins diet protocol, said Dr. Westman of the department of medicine, Duke University Medical Center in Durham, N.C.

Dr. Westman and his colleagues enrolled 119 overweight, hyperlipidemic volunteers. After 24 weeks, participants had an average 7-kg weight loss on a low-carbohydrate diet versus 6.8 kg on a low-fat, low-cholesterol, reduced-calorie protocol. Dr. Westman's research was supported by an unrestricted grant from the Dr. Robert C. Atkins Foundation.

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