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Reports of diarrhoea with carvedilol.(Safety and Efficacy Issues)
Carvedilol is a non-cardioselective beta-blocker with alpha blocking activity (1). It is indicated for the management of essential hypertension, angina pectoris and as adjunctive therapy in chronic heart failure (2). The New Zealand Centre for Adverse Reactions Monitoring (CARM) has received four reports of diarrhoea with carvedilol (Dilatrend[R]).
In three of the reports, severe diarrhoea developed within a week; and in the fourth case, the diarrhoea was moderate and began during the first month of carvedilol treatment. The doses of carvedilol ranged from 6.25 mg to 25 mg daily. All the individuals experienced improvement in their symptoms on stopping the medicine. …
