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Having a spontaneous or induced abortion does not increase a woman's subsequent risk of developing breast cancer, according to results from the most comprehensive analysis of its kind.
The finding comes from the Collaborative Group on Hormonal Factors in Breast Cancer, a group of experts that formed in 1992 to assemble the available scientific evidence between breast cancer and reproductive events, including pregnancies that end in abortion.
For the study, researchers analyzed 53 studies that included 83,000 women with breast cancer from 16 countries (Lancet 363[9414]:1007-16, 2004). Of the 83,000 women, 44,000 took part in prospective studies, while the rest (39,000) took part in what investigators described as less scientifically reliable retrospective studies.
The researchers calculated the relative risk of breast cancer among women in the 53 studies by comparing the effects of having a pregnancy that ended in abortion with those who had no such record. The women were stratified by study, age at diagnosis, parity, and age at first birth.
Their review of prospectively designed studies found no significant link between spontaneous or induced abortion and breast cancer.
Their review of retrospectively designed studies found no significant link between spontaneous abortion and breast cancer, but the overall results for induced ...