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Prevention strategy fails: prepregnancy antibiotics, preterm births linked.(Obstetrics)
NEW ORLEANS -- Prepregnancy antibiotic treatment in women with a prior preterm birth was tied to an increased risk of subsequent preterm birth and low birth weight in a randomized controlled trial.
Of 124 nonpregnant women with a prior preterm birth who conceived during the study, 59 were treated every 4 months with oral azithromycin (two 1-g doses administered 4 days apart) and sustained-release metronidazole (750 mg once daily for 7 days) until conception, and 65 received placebo.
The number of women in each group who experienced a subsequent spontaneous preterm birth before 37 weeks' gestation did not differ significantly, but the mean gestational age at delivery was slightly lower in the active treatment group (32 weeks vs. 34.4 weeks), Dr. William Andrews said at the annual meeting of the Society for Maternal-Fetal Medicine.
Birth weight was also lower in the active treatment group, and the difference, which was statistically significant, approached 500 g, said Dr. Andrews of the University of Alabama, Birmingham.
The findings surprised the investigators, who hypothesized that upper genital tract microbial infection associated with spontaneous preterm birth might precede conception, and that ...
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- Studies back progesterone injections to prevent preterm birth.(Women's Health)
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- Pre-Pregnancy Antibiotics Do Not Prevent Preterm Birth, Researchers Say.
- Press release article from: PR Newswire February 5, 2004 700+ words
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- Magazine article from: OB GYN News JANCIN, BRUCE May 1, 2001 700+ words
...lack of success in preventing preterm birth over the past 20 years really...basic underlying biology of preterm birth isn't yet understood. Until...not realistic to expect the preterm birth rate to fall, observed Dr...
- FDA Advisory Committee Recommends Approval of Adeza's NDA for Gestiva to...
- Press release article from: Business Wire August 30, 2006 700+ words
...TM) support efficacy in preventing preterm birth prior to 35 weeks and that overall...important therapeutic for the prevention of preterm birth in women with a history of preterm...officer. "With approximately one preterm birth every minute and a $26 billion annual...
