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Prophylactic surgery beneficial in Lynch syndrome.(Gynecology)
Prophylactic surgery may help to prevent gynecologic cancers in women with hereditary nonpolyposis colorectal cancer, reported Dr. Kathleen M. Schmeler of the University of Texas M.D. Anderson Cancer Center, Houston, and her associates.
In a retrospective study of a cohort of patients who had germ-line mutations associated with hereditary nonpolyposis colorectal cancer (Lynch syndrome), significantly fewer endometrial cancers occurred in women who had a prophylactic hysterectomy (0 of 61) than in those who did not (69 of 210).
None of the 47 women who had undergone a bilateral salpingo-oophorectomy for cancer prevention or benign conditions at the same time as their hysterectomy developed ovarian cancer, but this was not significantly different from the number of women in the control group who developed ovarian cancer (12 of 223).
The women underwent hysterectomy or bilateral salpingo-oophorectomy at a median age of 41 years, whereas the median age at diagnosis was 46 years for endometrial cancer and 42 years for ovarian cancer.
All but four of the endometrial and two of the ovarian cancers occurred in women older than 35 years, according to the investigators (N. Engl. J. Med. 2006;354:261-9).
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Source: HighBeam Research, Prophylactic surgery beneficial in Lynch syndrome.(Gynecology)