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Atherosclerosis protection afforded to some. (Estradiol Therapy).
ASHLAND, ORE. -- Obese postmenopausal women on lipid-lowering therapy appear to derive no additional protection against atherosclerosis when they take unopposed estradiol, but obese and nonobese women with normal cholesterol levels do seem to benefit.
That was the conclusion of a subgroup analysis of data derived from the Estrogen in the Prevention of Atherosclerosis Trial (EPAT), a randomized, double-blind, placebo-controlled trial that examined progression of subclinical atherosclerosis in healthy postmenopausal women. Results were presented in poster form at the annual meeting of the Pacific Coast Obstetrical and Gynecological Society.
In the study, 199 women were randomized to receive either unopposed estradiol or placebo. Progression of atherosclerosis was evaluated using sequential tests to detect changes in intima media thickness over 2 years.
A cutoff of 30 kg/[m.sup.2] was ...
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Source: HighBeam Research, Atherosclerosis protection afforded to some. (Estradiol Therapy).