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NEW ORLEANS -- Culture-positive neonatal infection is associated with development of white matter injury, which is a major precursor of neurologic impairment and cerebral palsy, Dr. Cynthia Holcroft said at the annual meeting of the Society for Maternal-Fetal Medicine.
Positive neonatal urine, blood, cerebrospinal fluid, and tracheal cultures each occurred more often among 150 babies with white matter injury than among 150 controls in a retrospective study of births between 23 and 34 weeks' gestation.
White matter injury in this study was characterized by periventricular leukomalacia or ventricular dilatation; the babies studied were free of other chromosomal abnormalities and congenital anomalies, said Dr. Holcroft of Johns Hopkins University, Baltimore. Compared with controls, the babies with white matter injuries had higher ...