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Preliminary results: individualize CA 125 levels for ovarian cancer risk assessment.(Gynecology)
SAN DIEGO -- A prospective, multicenter screening trial is investigating whether a longitudinal pattern of CA 125 measurements, rather than a single measurement, offers better sensitivity for detecting ovarian cancer in women at high risk for the disease.
"The interpretation of a woman's CA 125 level involves looking for an elbow pattern rise, over time, rather than evaluating a single absolute level," reported Dr. Steven Skates of Massachusetts General Hospital, Boston.
For further refinement of the measurement's sensitivity, variables such as menopausal status, race, bilateral salpingo-oophorectomy, and smoking also should be considered, because they can alter by at least 10% the critical cut point that indicates further investigation, he said at the annual meeting of the Society of Gynecologic Oncologists.
A total of 2,005 women from 23 U.S. academic medical centers have been enrolled in the trial to date. Of the five ovarian cancers that have been detected, four had levels commensurate with an elbow pattern of rising CA 125 levels. In general, approximately 15%-20% of ovarian cancers do not produce CA 125, Dr. Skates said.
Investigators in the study are using CA 125 levels, measured every 3 months as the first line of screening, followed by transvaginal ultrasonography (TVS) when indicated. Although they are ...
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Source: HighBeam Research, Preliminary results: individualize CA 125 levels for ovarian cancer...